CHEMICAL-SCIENCES
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Physicochemical properties play an important role in designing drugs, and also in the optimization process of the pharmaceutical product. The problem of low pharmaceuticals’ solubility became more significant, due to drugs in new therapeutic areas.
- Determination the basic physicochemical proper…
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ANTIBACTERIAL POLYMERS
Substantial number of people die worldwide every year due to bacterial infections related to antibiotic resistant strains. The problem is driving research of novel polymeric antibacterial substances. We are trying to create polymers with lytic activity against bacterial ce…
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ANTIFOULING MATERIALS
Biofouling is a process of accumulation of biological matter and growth of microorganisms, and higher organisms on surfaces. The phenomenon is present at any surface immersed in an aquatic environment, in any biological ecosystem, and, in the case of synthetic surfaces, it…
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SYNTHESIS AND MODYFICATION OF POLYMERES
In BioMat team we deal with synthesis of various polymeric materials. Particularly interesting part of this work is development of methods for controlled post polymerization modifications (c-PPM) so at the stage when polymeric main chain is already created…
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1. Research on the use of biotransformations in the synthesis of biologically active compounds.
2. Optimization of conditions for enzymatic kinetic/dynamic separations of racemic mixtures of secondary alcohols or their esters using hydrolases as catalysts.
3. Optimization of conditions for asymme…
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1. Design and synthesis of protein kinase inhibitors (CK2 and PIM-1).
2. Study of the effect of protein kinase inhibitors on cancer cell survival.
3. Structure-activity relationship studies (SAR).
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Design and synthesis of nitrogen-containing heterocycles exhibiting antifungal (in particular against Candida albicans), antimicrobial and antiviral activity.
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Breast and female reproductive tract cancers (gynecologic cancers) cause high mortality among women and are an important social problem. Recent studies of new anticancer compounds used to treat gynecological cancers are mainly based on 2D in vitro assays. Therefore, we propose research on the devel…
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Research concerns the development of advanced three-dimensional cellular models and new microfluidic systems where in vivo conditions can be simulated. To develop Organ-on-a-chip systems (Heart-on-a-chip, Inslet-on-a-chip) we used photolithography, microfabrication, and 3D printing. Another issue i…
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The research objective is the elaboration of affinity-based receptor layers for detection of analytes that are environmentally and clinically important. In the developed biosensors the recognition layers are formed of antibodies, nucleic acids and aptamers and detection techniques that are applied …
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Fast molecular diagnostics based on nucleic acid analysis enables the detection not only diseases caused by mutations in genes or the identification of pathogenic microorganisms but also the selection of an appropriate treatment method for each patient. Its development is related to the latest achi…
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Research topics:
• synthesis and studies of a various molecular switches for use in photopharmacology;
• application of NMR spectroscopy to the analysis of metabolic diseases markers.
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Development of a lab-on-a-chip system to improve sperm parameters
Infertility is a global health problem that affects a large part of the population. One of its causes is male infertility, which has been increasing for some time. Thanks to assisted reproductive methods, it is possible to solve thi…
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Development and application of magnetic nanoparticles in the procedure of photothermal therapy
Photothermal therapy involves the use of local heating of the tissues, resulting in the “relaxation” of the cell membrane and denaturation of the proteins, leading to cell death. In this therapy, phototh…
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New drugs, effective especially in civilization diseases, are constantly in demand. However, introducing a new active substance to the market is very costly, which results in a relatively small number of new drugs appearing in the world every year. Often, even promising molecules may have low bioav…
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Our scientific activity has a multidisciplinary character and the research interests range from fundamental inorganic and organometallic chemistry to supramolecular chemistry to catalysis, materials science, and nanotechnology. A distinctive feature of our investigations is transferring curiosity-d…
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Alternative solvents (ionic liquids, deep eutectic solvents) - physico-chemial & thermodynamic properties, modeling and computer-aided molecular design with a variety of methods (empirical correlations, thermodynamic equations of state, hybric method (thermodynamics + quantum chemistry, COSMO-RS)
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Applying chemoinformatics and machine learning in developing new QSPR empirical correlations/models (QSPR = quantitative structure-property relationship) for describing and predicitng a variety of systems and physico-chemial properties.
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Surface-active proteins enable stabilization of emulsion and foam systems, e.g. in the food industry. Today, the animal-derived proteins (e.g. lactoglobulins, caseins, albumin) are mostly employed for this purpose, but the environmental cost of their production is very high. It stems mainly from th…
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Saponins belong to biosurfactants - surface active compounds produced by living organisms. In addition to surface activity, saponins display important biological activity due to their ability to reduce surface tension or create foams. Previous studies have shown that biological activity of saponins…
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Separation techniques (liquid chromatography and capillary electrophoresis) combined with mass spectrometry make it possible to follow changes in the content of several to thousands of small-molecule compounds in biological or environmental origin materials. Their usefulness depends on the fraction…
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Mass spectrometry combined with liquid chromatography-mass spectrometry (LC-MS) is increasingly used in routine medical diagnostics. It happened because LC-MS methods for determining markers of metabolic disorders provide unique sensitivity and selectivity. However, a significant disadvantage of th…
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Nowoczesne techniki sprzężone umożliwiają identyfikację i oznaczanie substancji aktywnych w produktach i … More
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Single particle microwave induced plasma optical emission spectrometry (sp-MWP-OES) is a unique, multi-purpose analytical technique, developed in our lab for multielement analysis of nanopowders. It can be applied for the investigation of particle-by particle reproducibility of chemical composition…
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Among modern separation/preconcentration techniques used for trace amounts of analytes, those called solventless techniques eg. solid phase microextraction are of particular interest. In a such of separation process, the analyte transport efficiency between the liquid sample phase and the headspace…
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- Trace and speciation analysis of selected elements in food and diet supplements
- Bioavailability investigation of selected elements species by the human organism
- Hyphenated techniques (separation techniques - HPLC/CE coupled with specific detection techniques - ICP-MS/ESI-MS) in speciation a…
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- Bioavailability investigation of selected nanoparticles (NPs)
- Investigation of nanoparticles (NPs) metabolism in edible plants
- New extraction methods of nanoparticles from plant tissue and food - ionic liquids, NADES
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Hyphenated Techniques in the examination of skin penetration by metals species from cosmetics
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Electrolytes for galvanic cells – design, synthesis and investigation of electrolytes for lithium, lithium-ion (Li-ion) and beyond-lithium-ion cells (sodium-ion (Na-ion), lithium-sulfur, etc.), with particular focus on design and application of new/proprietary lithium salts and functional additives…
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Chemistry of weakly-coordinating anions – synthesis of alkali metal salts and ionic liquids containing weakly-coordinating anions, design of new synthesis routes, optimization and upscaling of syntheses, design and modeling of new compounds/moieties, development of new weakly-coordinating anions fo…
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Ionic liquids in reference electrodes for biomedical measurements One sample that can be used for non-invasive biomedical measurements is sweat. So-called ""electronic tattoos"" have been proposed for continuous measurement of sweat. They are non-invasive analytical devices with sensors placed on t…
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Transducing layers for anion-selective electrodes with polymer membranes
The aim of the proposed research is to investigate the possibility of improving the analytical parameters of miniaturized ion-selective electrodes for selected anions through the use of various types of transducing layers. …
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The research area covers developing a structural approach based on extensive single-crystal X-ray diffraction studies as a tool for designing and evaluating novel electrolyte systems. The method involves crystallization experiments of several solvates of selected heterocyclic salts and their crysta…
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Smart systems for hydrogen economy and distributed, prosument and renewable energetic systems utilizing electrochemical energy stores and fuel cells of various design and functionality. Machine learning tools focused on automated diagnostic of industrial electrochemical components. Development of e…
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Novel materials for hydrogen economy and renewable energy systems. Chemistry, physical chemistry and electrochemistry of functional materials such as electrolytes for water electrolysis, galvanic and fuel cells, electrode materials, materials for micro and optoelectronics. Scope covers molecular en…
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Obtaining, characterizing and optimizing the production of fusion polymerases enabling the effective implementation of the genetic material amplification reaction directly in clinical samples in a much faster manner than the counterparts available on the market.
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My team is involved in research on Phase Change Materials (PCM). PCM are substances or mixtures which, as a result of phase transitions (solid – liquid, solid – solid, vapor-liquid) maintain a constant temperature while they take or give away the so-called latent heat. PCMs can have different appli…
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As part of my scientific research, the desulfurization of fuels using Ionic Liquids, ILs and Deep Eutectic Solvents, DES is my challenge. Deep desulfurization of liquid fuels is an important and difficult problem in the global refining industry and is a challenge for many scientific laboratories a…
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Recently, a new generation of compounds – Ionic liquids (ILs) – has been of particular interest from the point of view of applied research. They are defined as compounds that have a melting point below 100oC. Ionic liquids are made up of a large organic, often asymmetrical cation and a smaller org…
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Energy storage (lithium - ion, sodium-ion etc.), renewable energy, electro mobility, sustainable-energy
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Design and synthesis of organic compounds - receptors of the selected ions, ie. cations or anions of interest from the environmental protection-point of view. So for this purpose, the newly synthesized derivatives will bear analyte-binding structural motifs (amide group, azole moiety - 1,2,3-triazl…
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Design and synthesis of novel organic compounds, potential anticancer agents with special regard to mutual prodrugs. A mutual prodrug is the association in a unique molecule of two, usually synergistic, drugs attached to
each other, one drug being the carrier for the other and vice versa. (C. G. W…
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Synthesis, studies on properties and application of nanoparticles in the construction of biotests and biosensors - the research will involve synthesizing hybrid nanoparticles with the desired magnetic, optical and catalytic properties, which after surface modification with selected receptors (antib…
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Studies on interactions of clinically significant analytes with the receptor layers using label-free analytical techniques - the research will be focused on investigations of new receptors enabling the development of biosensors and biotests for the detection or determination of clinically relevant …
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Synthesis and application of nanoparticles in therapies - as part of the research, nanoparticles with the desired optical, magnetic and catalytic properties, which can be used in anti-cancer therapies through the ability to generate heat under the influence of infrared radiation, the applied magnet…
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The area of scientific research concerns the search for new systems of ionic liquids in terms of the possibility of application in absorption refrigeration technology. The main objective of the work is the thermodynamic and physicochemical characterization of pure ionic liquids as absorbents and th…
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The area of scientific research concerns the determination and correlation of the basic thermodynamic and physicochemical properties of a new class of pure organic salts and their binary systems with aliphatic and aromatic hydrocarbons and with water. The conducted research is aimed at determining …
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The main research interests are focused on the design and fabrication of bioanalytical microsystems (Lab-on-a-Chip flow-through microsystems). These microsystems are intended for the development of new analytical and bioanalytical procedures such as: conducting analytical reactions at the microscal…
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Searching for antiviral drugs - identification of new indications for drugs (drug repurposing) against COVID 19. Studies on the mast cell activation syndrome (MC) and the role of MC in the inflammatory process responsible for the severe course of COVID-19 will help identify new targets for anti-COV…
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Understanding the action mode of oncolytic therapy, tumor biology, and specific studies of the immune response. Development of new and more effective methods of cancer treatment (e.g. pleural mesothelioma) using an oncolytic virus encoding ICOS ligand in combination with an anti-PD-1 checkpoint inh…
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Studies on the calcineurin signaling pathway in the innate immune response over pathogenic fungal infections. Regulatory interaction analyzes of the Candida calcineurin subunit Cal albicans (coded by the CNB1 gene) with mast cells (mast cells) – sensors congenital and acquired immunity effectors. D…
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Spectroscopic ""fingerprints"" of cells – acquisition and numerical analysis.
Thanks to their uniqueness, fingerprints are one of the basic biometric features used to identify people. Identification techniques in chemistry can also rely on the recognition of ""patterns"" - that is, signal pattern…
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""Fingerprints"" of quantum dots for analytical and bioanalytical purposes.
The subject of the PhD thesis is related to the use of nanomaterials - quantum dots - to create fluorescent ""fingerprints"" for the identification / determination of selected bioanalytes with a similar structure: amino a…
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Ion-sensitive nano- and microspheres - fabrication, characterization and testing of sensory properties.
In recent years, nanotechnology has developed a number of tools enabling the fabrication, characterization, and study of the potential applications of a number of nanomaterials, which we use mo…
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Electronic tongue - study of the correlation of (soft) sensor signals with organoleptic properties.
The ""Holy Grail"" of the pharmaceutical and food industry is the replacement of trained organoleptic evaluation experts (human panel) with machine-based taste and smell systems, so-called taste a…
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The research topic involves design of luminescent compounds with a special emphasis on systems that exhibit Thermally Activated Delayed Fluorescence (TADF). The research will mainly devoted to using novel heterocyclic organoboron cores, featuring strongly electron-acceptor properties, as key build…
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Thermodynamics of solutions, i.e., thermodynamic and physical properties of liquid mixtures. Phase equilibria (vapor-liquid, liquid-liquid, solid-liquid) in binary and multicomponent systems. The excess functions of mixing - Gibbs function, enthalpy and volume. Relationships between the properties …
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Melanoma is the skin cancer with the highest mortality and increasing incidence in the world population. Despite many years of efforts, there is no effective therapy for metastasis of this cancer and a lot of research is devoted to searching for new solutions using the modern methods and technologi…
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Exosomes are extracellular signaling molecules secreted by eukaryotic cells, the presence of which in body fluids makes them a potential and easily accessible biomarkers of various pathological processes, including cancer. Taking blood serum rich in exosomes from patients with cancer is a simple an…
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My research group works on new materials for energy storage devices such as batteries and supercapacitors. The recent breakthrough studies of the group has led to the design and development of a novel family of Huckel-type salts for application in electrolytes used in lithium and/or sodium ion bat…
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Organometallic chemistry of transition metals and homogeneous catalysis, in particular:
synthesis of novel homochiral ligands based on ansa-ferrocenes and their application in asymmetric catalysis
olefin metathesis in transition metal coordination spheres catalysed with Grubbs catalysts (I or II …
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Electrochemical sensors based on novel molecular receptors
Chemical sensors are attractive analytical devices, which can deliver real-time and on-line information on the presence of specific compounds in complex samples. Due to their high selectivity, sensitivity and wide spectrum of design soluti…
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Modern multi-sensor systems (electronic tongue) for the analysis of pharmaceuticals
Electronic tongue is a modern device that provide automatic analysis and classification (including identification and quality assessment) of complex samples. Specially selected set of cross-sensitive sensors (senso…
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Redox activity of metal-peptide complexes
Peptides are essential biomolecules associated with learning and neurodegeneration processes (Aβ peptides), the innate immune response (histatins) and wound healing (a GHK peptide). It should be emphasized that in many cases, the biological activity of suc…
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Development of methods for the elemental analysis of materials from the oil industry, especially crude oil and petroleum products, catalysts for oil processing, biofuels, environmental samples, sludges and wastes. Some elements poison catalysts for oil processing, pose corrosive hazards and pollute…
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Moje zainteresowania badawcze obejmują chemię strukturalną związków zawierających stereoaktywne wolne pary elektronowe. Realizuję je poprzez badanie związków arsenu i antymonu na +3 stopniu utlenienia pod ciś… More
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Chemia metaloorganiczna - Synteza z udziałem związków litoorganicznych. Synteza i badanie właściwości związków boroorganicznych. Badanie właściwości luminescencyjnych związków metaloorganicznych - wpływ oddziaływań wewnątrz- oraz międzycząsteczkowych na aktywność luminescenc… More
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Metaloorganic chemistry - synthesis via organolithium compounds. Synthesis and characterization of organoboron compounds. Luminescent properties of metaloorganic compounds - the influence of intra- and intermolecular interactions on the luminescent activity. Photochemistry - application of photo… More
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Synthesis and technology of biologically active compounds (drugs, biocides). Asymmetric synthesis. Biotransformations using enzymes and microorganisms leading to obtaining optically active compounds. The use of microwaves and mechanochemical methods in the synthesis of valuable compounds. More
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Badania dzieł sztuki nie ograniczają się obecnie do analizy historycznej bądź artystycznej wartości dzieł… More
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Opracowanie nowego leku, od pierwotnego pomysłu do wprowadzenia gotowego produktu na rynek, jest procesem… More
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Od lat pięćdziesiątych XX wieku wyprodukowano ponad 8,3 miliarda ton plastiku, z czego 16% stanowią opakowania żywności. Tworzywa sztuczne ulegają fotoutleniania, kruszeniu, pękaniu, ścieraniu, erozji, biodeg… More
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My scientific interests include the organic and supramolecular chemistry, mostly related to the design of novel chemical molecular receptors based on polyaromatic compounds. Research works merge the preparative organic chemistry with the studies on non-covalent interactions of the designed compo… More
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Crystallization and research on the crystal structure and electrical and magnetic properties of inorganic and hybrid functional materials (superconductors, magnetic materials, thermoelectric materials and semiconductors) for potential applications in energy conversion, signal detection systems, … More
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The use of electrospun materials in the construction of modern bioanalytical tools - Electrospinning is a modern technique for producing polymeric mats (both from natural and synthetic polymers) with an expanded surface area and high porosity. The method also makes it possible to produce composi… More
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Synthesis and research on rheological properties of electrheological materials (liquids, gels and… More
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Research interests include: fibre optic chemical sensors; lab-on-paper chemical sensors; technology, design and fabrication of microfluidic structures for analytical microsystems applications, lab-on-a-chip. More
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In recent years, an increasing number of various methods for obtaining nanometric gold structures have been observed. These nanomaterials can be applied in many branches of everyday life, including medicine. De… More
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Liposomes are nanosized vesicles built from a phospholipid double layer. Currently, intensive works are carried out on the broad application of this type of nanomaterials in more effective delivery of active co… More
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Metal-based nanoparticles are increasingly being considered as fertilizer additives, enabling more effective plant growth and ensuring their greater resistance to diseases. Unfortuna… More
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My research focuses on the chemistry of photoactive organoboron compounds. The main objective is to understand how specific photoactive properties such as thermally activated delayed fluorescence (TADF), room temperature phosphorescence (RTP), aggregation-induced emission (AIE), triplet-triplet … More
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