Wykaz obszarów badawczych związanych z tagiem Burza-cytokin:
| # | Obszar badawczy | Dziedzina naukowa |
|---|---|---|
| 1 |
Searching for antiviral drugs - identification of new indications for drugs (drug repurposing) against COVID 19. Studies on the mast cell activation syndrome (MC) and the role of MC in the inflammatory process responsible for the severe course of COVID-19 will help identify new targets for anti-COVID-19 drugs. The study of the effect of cromoglycan (an authorized drug) as well as potential active substances - developed and tested in vitro and in vivo by our team) in inhibiting the ""cytokine storm"". Research on the inhibition of MC cell degranulation in response to SARS-CoV-2.
Collaboration with bioinformatics to select in silico substances that will be used in in vitro and ex vivo tests to confirm the mechanism of their action as well as their effectiveness in inhibiting SARS-CoV-2 infection. Analysis of the role of MC in inducing a ""cytokine storm"" (i) inhibiting it by blocking MC degranulation, and (ii) inhibiting viral replication. Understanding the molecular functions of mast cells (MC) in COVID-19 and selecting therapeutic solutions in experiments. The research will be conducted with the use of pseudo-SARS-CoV-2, as well as in the cooperation with NIZP-PZH BIP (BSL3).
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