Wykaz obszarów badawczych związanych z tagiem Leki-przeciwnowotworowe:
| # | Obszar badawczy | Dziedzina naukowa |
|---|---|---|
| 1 |
Design and synthesis of novel organic compounds, potential anticancer agents with special regard to mutual prodrugs. A mutual prodrug is the association in a unique molecule of two, usually synergistic, drugs attached to
each other, one drug being the carrier for the other and vice versa. (C. G. Wermuth, C. R. Ganellin, P. Lindberg and L. A. Mitscher w Glossary of Terms Used in Medicinal Chemistry. IUPAC Recommendations 1998. https://doi.org/10.1515/iupac.70.0050). The synthesized prodrugs will be examined in terms of their biological activity. Next, they will be employed as the active agents of novel drug delivery systems based on organic macromolecules. Biological studies on the obtained prodrugs and drug delivery systems will be examined in cooperation with prestigious scientific teams.
|
|
| 2 |
Although cisplatin and oxaliplatin are anticancer drugs frequently applied in the chemotherapy of various malignant neoplasms, their non-selective transportation into cells results in serious side effects of treatment. Non-toxic nanomaterials such as liposomes can be used to ensure the drug's targeted delivery. In addition, features such as biocompatibility (similarity to cell membranes), biodegradability, ease of synthesis and surface modification, and the ability to regulate the degree of drug encapsulation distinguish them from other nanomaterials tested as drug nanocarriers. Even though at least a few liposome systems have been approved for the market, none contain platinum drugs. This situation may result in the utilization of ineffective analytical tools for their characterization. As part of the proposed research, methodologies for studying changes in in vitro liposomal systems of targeted cisplatin/oxaliplatin delivery using techniques based on mass spectrometry detection will be developed.
|