Wykaz obszarów badawczych związanych z tagiem Chromatography:
| # | Obszar badawczy | Dziedzina naukowa |
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| 1 |
In recent years, an increasing number of various methods for obtaining nanometric gold structures have been observed. These nanomaterials can be applied in many branches of everyday life, including medicine. Despite the rapid progress in their synthesis, the characterization methods are developing slower, which induces the need for their effective elaboration. Within the presented research area, a modern analytical platform for studying the combinations of gold nanomaterials with anticancer drugs in complex sample matrices using advanced mass spectrometry techniques, including mass spectrometry with ionization in inductively coupled plasma in single particle or single cell analysis mode, will be proposed. The use of such techniques may enable an understanding of many processes to which these metallic nanomaterials are subjected in the body.
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| 2 |
Liposomes are nanosized vesicles built from a phospholipid double layer. Currently, intensive works are carried out on the broad application of this type of nanomaterials in more effective delivery of active compounds, e.g., in dietary supplements. Unfortunately, it is a lack of studies confirming the increased bioavailability of active compounds from liposomal preparations than from classic ones. Therefore, research aimed at understanding their metabolic pathways (and comparing them with supplements in which nanomaterials are not used) in conditions that simulate the human body is a significant issue. As part of the dissertation, the changes mentioned above concerning selected supplements, e.g., zinc or vitamin B12, will be tested using, on the one hand, modern methods of in vitro simulation (enzymatic digestion/degree of absorption into intestinal villus cell lines), and on the other hand, high-sensitive mass spectrometry detection techniques.
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| 3 |
Metal-based nanoparticles are increasingly being considered as fertilizer additives, enabling more effective plant growth and ensuring their greater resistance to diseases. Unfortunately, despite great interest in introducing this type of nanostructures into circulation, there is a lack of research focused on understanding their metabolic pathways in the human body and the forms in which they are absorbed by the human body. As part of the dissertation, analytical methods will be developed, using mass spectrometry detection techniques - both molecular and atomic, thanks to which the transformations of selected metal nanoparticles will be examined in vitro - from simulating the digestive processes of selected edible farmed plants to identifying the forms of metals absorbed by intestinal cilia cell lines
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