Wykaz obszarów badawczych związanych z tagiem Nowotwory:
| # | Obszar badawczy | Dziedzina naukowa |
|---|---|---|
| 1 |
My research focuses on determining the anticancer potential of various active compounds. In particular, the research is concerned with determining the cytotoxicity of potential drugs against various cancer and normal lines, determining the type of cell death (apoptosis, autophagy) and activation of selected signaling pathways in the cell. Most of the ongoing research involves inhibitors of protein kinases CK2 and PIM and their use in leukemia and breast cancer therapy. Ongoing research also includes determining synergistic interactions of selected protein kinase inhibitors together with classical cytostatics. Recent research includes the use of human exosomes to improve the efficacy of selected CK2 inhibitors on cancer cells. Methods he specializes in include MTT assay (determination of IC50 values, combination indices (CI), dose reduction index (DRI)), flow cytometry methods, immunodetection (western blot), immunofluorescence (fluorescence, confocal microscopy).
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| 2 |
In recent years, an increasing number of various methods for obtaining nanometric gold structures have been observed. These nanomaterials can be applied in many branches of everyday life, including medicine. Despite the rapid progress in their synthesis, the characterization methods are developing slower, which induces the need for their effective elaboration. Within the presented research area, a modern analytical platform for studying the combinations of gold nanomaterials with anticancer drugs in complex sample matrices using advanced mass spectrometry techniques, including mass spectrometry with ionization in inductively coupled plasma in single particle or single cell analysis mode, will be proposed. The use of such techniques may enable an understanding of many processes to which these metallic nanomaterials are subjected in the body.
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