Wykaz obszarów badawczych związanych z tagiem Nowotwory:
| # | Obszar badawczy | Dziedzina naukowa |
|---|---|---|
| 1 |
My research focuses on determining the anticancer potential of various active compounds. In particular, the research is concerned with determining the cytotoxicity of potential drugs against various cancer and normal lines, determining the type of cell death (apoptosis, autophagy) and activation of selected signaling pathways in the cell. Most of the ongoing research involves inhibitors of protein kinases CK2 and PIM and their use in leukemia and breast cancer therapy. Ongoing research also includes determining synergistic interactions of selected protein kinase inhibitors together with classical cytostatics. Recent research includes the use of human exosomes to improve the efficacy of selected CK2 inhibitors on cancer cells. Methods he specializes in include MTT assay (determination of IC50 values, combination indices (CI), dose reduction index (DRI)), flow cytometry methods, immunodetection (western blot), immunofluorescence (fluorescence, confocal microscopy).
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| 2 |
In recent years, a growing number of diverse methods for obtaining nanometric structures have been observed. These nanomaterials can find applications in many areas of everyday life, including medicine. Despite the rapid development of synthetic techniques, methodologies for characterizing the produced chemical entities have developed somewhat more slowly, which necessitates their efficient development. Within the presented research area, a modern analytical platform will be proposed for studying the encapsulation processes of anticancer drugs in liposomes carrying magnetic nanoparticles and their transformations under conditions simulating the human body using advanced mass spectrometry techniques, including inductively coupled plasma mass spectrometry in single-cell analysis mode.
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