Wykaz obszarów badawczych związanych z tagiem Oddzialywania-powinowactwa:
| # | Obszar badawczy | Dziedzina naukowa |
|---|---|---|
| 1 |
Fast molecular diagnostics based on nucleic acid analysis enables the detection not only diseases caused by mutations in genes or the identification of pathogenic microorganisms but also the selection of an appropriate treatment method for each patient. Its development is related to the latest achievements in the field of microfluidic systems and integrated sensors and biosensors. This combination allows for efficient and fully automatic preparation of biological material samples and their analysis.
At this area research is focused on the development of new electrochemical sensors dedicated to effective and selective detection of selected nucleic acid sequences. In particular, samples derived from isothermal DNA amplification reactions will be considered. The high content of proteins in such samples force the use of new approaches leading to the elimination of their influence on the processes taking place at the electrode/solution interface. In particular, this applies to selected nanomaterials and elements of biosensitive receptor layers that eliminates the possibility of non-specific protein adsorption.
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| 2 |
Studies on interactions of clinically significant analytes with the receptor layers using label-free analytical techniques - the research will be focused on investigations of new receptors enabling the development of biosensors and biotests for the detection or determination of clinically relevant analytes (mainly disease biomarkers). The research will be based on techniques enabling the determination of kinetic and thermodynamic parameters of interactions used in the construction of such devices (bioreceptor - biomarker), e.g. SPR.
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