Wykaz obszarów badawczych związanych z tagiem Techniki-łączone:
| # | Obszar badawczy | Dziedzina naukowa |
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| 1 |
In recent years, an increasing number of various formation methods of metal-based nanometric structures has been notified. These nanomaterials can be applied in many branches of life, including medicine and agriculture. Despite the fast development of the synthetic methods, these dedicated to characterizing the produced chemical structures progressed slower, which induces the acute need for their practical elaboration. As part of the presented research area, a modern analytical platform will be proposed to study selected metal-based nanomaterials (or their connections with drugs) in complex sample matrices using advanced mass spectrometry techniques, including single-particle or single-cell inductively coupled plasma mass spectrometry. Such techniques may enable understanding of many processes that metallic nanomaterials undergo in the environment or living organisms.
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| 2 |
Although cisplatin and oxaliplatin are anticancer drugs frequently applied in the chemotherapy of various malignant neoplasms, their non-selective transportation into cells results in serious side effects of treatment. Non-toxic nanomaterials such as liposomes can be used to ensure the drug's targeted delivery. In addition, features such as biocompatibility (similarity to cell membranes), biodegradability, ease of synthesis and surface modification, and the ability to regulate the degree of drug encapsulation distinguish them from other nanomaterials tested as drug nanocarriers. Even though at least a few liposome systems have been approved for the market, none contain platinum drugs. This situation may result in the utilization of ineffective analytical tools for their characterization. As part of the proposed research, methodologies for studying changes in in vitro liposomal systems of targeted cisplatin/oxaliplatin delivery using techniques based on mass spectrometry detection will be developed.
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| 3 |
Liposomes are nanometric vesicles built from a double phospholipid layer. Currently, intensive work is carried out on the broad application of nanomaterials in the more effective delivery of cosmetically active compounds. Although liposomes have several advantages, they are problematic analytical objects. As a result, it is difficult to identify the pathways for releasing active compounds from them to their target sites. These conditions create a unique research niche and motivation to propose an analytical platform based on tandem elemental mass spectrometry techniques to study changes in the liposome-cosmetic compound systems under conditions simulating stratum corneum. This methodology will be an essential source of knowledge about the pathways of selective trafficking of active compounds of crucial importance for the development of modern cosmetics (e.g., GHK tripeptide complex with Cu - anti-aging effect, selenium sulfide - anti-dandruff effect).
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| 4 |
Liposomes are nanosized vesicles built from a phospholipid double layer. Currently, intensive works are carried out on the broad application of this type of nanomaterials in more effective delivery of active compounds, e.g., in dietary supplements. Unfortunately, it is a lack of studies confirming the increased bioavailability of active compounds from liposomal preparations than from classic ones. Therefore, research aimed at understanding their metabolic pathways (and comparing them with supplements in which nanomaterials are not used) in conditions that simulate the human body is a significant issue. As part of the dissertation, the changes mentioned above concerning selected supplements, e.g., zinc or vitamin B12, will be tested using, on the one hand, modern methods of in vitro simulation (enzymatic digestion/degree of absorption into intestinal villus cell lines), and on the other hand, high-sensitive mass spectrometry detection techniques.
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