Wykaz obszarów badawczych:
| # | Research Area | Dziedzina naukowa |
|---|---|---|
| 1 |
The PhD thesis will focus on developing a research methodology combining Organ-on-Chip technology with high-resolution mass spectrometry to monitor interorgan communication and assess therapy efficacy and safety. The project will develop multi-organ microfluidic systems that replicate the physiological connections between selected tissues, including the liver, and drug target tissues. The use of mass spectrometry will enable the quantitative analysis of metabolites, biomarkers, and drug biotransformation products in real time. The result will be a comprehensive methodology supporting preclinical research, identifying mechanisms of drug action, and predicting their efficacy and systemic toxicity.
Additional information Assistant supervisor: dr inż. Agnieszka Żuchowska. |
Chemical-Sciences |
| 2 |
In recent years, a growing number of diverse methods for obtaining nanometric structures have been observed. These nanomaterials can find applications in many areas of everyday life, including medicine. Despite the rapid development of synthetic techniques, methodologies for characterizing the produced chemical entities have developed somewhat more slowly, which necessitates their efficient development. Within the presented research area, a modern analytical platform will be proposed for studying the encapsulation processes of anticancer drugs in liposomes carrying magnetic nanoparticles and their transformations under conditions simulating the human body using advanced mass spectrometry techniques, including inductively coupled plasma mass spectrometry in single-cell analysis mode.
|
Chemical-Sciences |
| 3 |
Liposomes are nanosized vesicles built from a phospholipid double layer. Currently, intensive works are carried out on the broad application of this type of nanomaterials in more effective delivery of active compounds, e.g., in dietary supplements. Unfortunately, it is a lack of studies confirming the increased bioavailability of active compounds from liposomal preparations than from classic ones. Therefore, research aimed at understanding their metabolic pathways (and comparing them with supplements in which nanomaterials are not used) in conditions that simulate the human body is a significant issue. As part of the dissertation, the changes mentioned above concerning selected supplements, e.g., zinc or vitamin B12, will be tested using, on the one hand, modern methods of in vitro simulation (enzymatic digestion/degree of absorption into intestinal villus cell lines), and on the other hand, high-sensitive mass spectrometry detection techniques.
|
Chemical-Sciences |