Doctoral Schools WUT

1. Research on the use of biotransformations in the synthesis of biologically active compounds. 2. Optimization of conditions for enzymatic kinetic/dynamic separations of racemic mixtures of secondary alcohols or their esters using hydrolases as catalysts. 3. Optimization of conditions for asymme… More

• Promoter Ph.D., D.Sc. Edyta Sylwia Łukowska-Chojnacka
• Keywords: Biokataliza | Enzymy | Kinetyczny rozdział dynamiczny | Rozdział kinetyczny |

1. Design and synthesis of protein kinase inhibitors (CK2 and PIM-1). 2. Study of the effect of protein kinase inhibitors on cancer cell survival. 3. Structure-activity relationship studies (SAR). More

• Promoter Ph.D., D.Sc. Edyta Sylwia Łukowska-Chojnacka
• Keywords: Aktywność przeciwnowotworowa | Inhibitor | Kinaza | Synteza organiczna |

Design and synthesis of nitrogen-containing heterocycles exhibiting antifungal (in particular against Candida albicans), antimicrobial and antiviral activity. More

• Promoter Ph.D., D.Sc. Edyta Sylwia Łukowska-Chojnacka
• Keywords: Aktywność przeciwbakteryjna | Aktywność przeciwgrzybicza | Aktywność przeciwwirusowa | Azole |

Breast and female reproductive tract cancers (gynecologic cancers) cause high mortality among women and are an important social problem. Recent studies of new anticancer compounds used to treat gynecological cancers are mainly based on 2D in vitro assays. Therefore, we propose research on the devel… More

• Promoter Ph.D., D.Sc. Elżbieta Jastrzębska
• Keywords: Cancer-on-a-chip system | Inżynieria komórkowa | Nowotwory ginekologiczne | Spektroskopia impedancyjna |

Research concerns the development of advanced three-dimensional cellular models and new microfluidic systems where in vivo conditions can be simulated. To develop Organ-on-a-chip systems (Heart-on-a-chip, Inslet-on-a-chip) we used photolithography, microfabrication, and 3D printing. Another issue i… More

• Promoter Ph.D., D.Sc. Elżbieta Jastrzębska
• Keywords: Inżynieria komórkowa | Mikrosystemy | Systemy Organ-on-a-chip | Unaczynienie |

The research objective is the elaboration of affinity-based receptor layers for detection of analytes that are environmentally and clinically important. In the developed biosensors the recognition layers are formed of antibodies, nucleic acids and aptamers and detection techniques that are applied … More

• Promoter prof. Elżbieta Janina Malinowska
• Keywords: Aptamery | Biosensory | Techniki elektrochemiczne | Warstwy receptorowe powinowactwa |

Fast molecular diagnostics based on nucleic acid analysis enables the detection not only diseases caused by mutations in genes or the identification of pathogenic microorganisms but also the selection of an appropriate treatment method for each patient. Its development is related to the latest achi… More

• Promoter prof. Elżbieta Janina Malinowska
• Keywords: Detekcja elektrochemiczna | Diagnostyka molekularna | Oddziaływania powinowactwa | Układy mikroprzepływowe |

Research topics: • synthesis and studies of a various molecular switches for use in photopharmacology; • application of NMR spectroscopy to the analysis of metabolic diseases markers. More

• Promoter Phd Hanna Anna Krawczyk
• Keywords: Badania NMR | Fotofarmakologia | Przełączniki molekularne |

Development of a lab-on-a-chip system to improve sperm parameters Infertility is a global health problem that affects a large part of the population. One of its causes is male infertility, which has been increasing for some time. Thanks to assisted reproductive methods, it is possible to solve thi… More

• Promoter Ph.D., D.Sc. Ilona Patrycja Grabowska-Jadach
• Keywords: Mikrosystem | Morfologia plemników | Selekcja plemników | Żywotność plemników |

Development and application of magnetic nanoparticles in the procedure of photothermal therapy Photothermal therapy involves the use of local heating of the tissues, resulting in the “relaxation” of the cell membrane and denaturation of the proteins, leading to cell death. In this therapy, phototh… More

• Promoter Ph.D., D.Sc. Ilona Patrycja Grabowska-Jadach
• Keywords: Modyfikacja powierzchni | Nanocząstki magnetyczne | Synteza nanocząstek | Terapia fototermiczna |

New drugs, effective especially in civilization diseases, are constantly in demand. However, introducing a new active substance to the market is very costly, which results in a relatively small number of new drugs appearing in the world every year. Often, even promising molecules may have low bioav… More

• Promoter Ph.D., D.Sc. Izabela Dorota Madura
• Keywords: Dyfrakcja rentgenowska | Formy krystaliczne | Inżynieria krystaliczna | Substancje aktywne farmacutycznie |

Our scientific activity has a multidisciplinary character and the research interests range from fundamental inorganic and organometallic chemistry to supramolecular chemistry to catalysis, materials science, and nanotechnology. A distinctive feature of our investigations is transferring curiosity-d… More

• Promoter prof. Janusz Zbigniew Lewiński
• Keywords: Chemia koordynacyjna i metaloorganiczna | Kropki kwantowe | Materiały porowate | Mechanochemia | Nanotechnologia | Perowskity |

Alternative solvents (ionic liquids, deep eutectic solvents) - physico-chemial & thermodynamic properties, modeling and computer-aided molecular design with a variety of methods (empirical correlations, thermodynamic equations of state, hybric method (thermodynamics + quantum chemistry, COSMO-RS) More

• Promoter Ph.D., D.Sc. Kamil Paduszyński
• Keywords: Ciecze jonowe | Modelowanie | Termodynamika chemiczna |

Applying chemoinformatics and machine learning in developing new QSPR empirical correlations/models (QSPR = quantitative structure-property relationship) for describing and predicitng a variety of systems and physico-chemial properties. More

• Promoter Ph.D., D.Sc. Kamil Paduszyński
• Keywords: Chemoinformatyka | QSPR | Uczenie maszynowe |

Surface-active proteins enable stabilization of emulsion and foam systems, e.g. in the food industry. Today, the animal-derived proteins (e.g. lactoglobulins, caseins, albumin) are mostly employed for this purpose, but the environmental cost of their production is very high. It stems mainly from th… More

• Promoter prof. Kamil Dominik Wojciechowski
• Keywords: Białka | Biosurfaktanty | Granice faz | Koloidy |

Saponins belong to biosurfactants - surface active compounds produced by living organisms. In addition to surface activity, saponins display important biological activity due to their ability to reduce surface tension or create foams. Previous studies have shown that biological activity of saponins… More

• Promoter prof. Kamil Dominik Wojciechowski
• Keywords: Biosurfaktant | Monowarstwa | Napięcie powierzchniowe | Saponin |

Separation techniques (liquid chromatography and capillary electrophoresis) combined with mass spectrometry make it possible to follow changes in the content of several to thousands of small-molecule compounds in biological or environmental origin materials. Their usefulness depends on the fraction… More

• Promoter Ph.D., D.Sc. Katarzyna Monika Pawlak
• Keywords: Chemometria | Metabolomika | Spektrometria mas | Techniki rozdzielania |

Mass spectrometry combined with liquid chromatography-mass spectrometry (LC-MS) is increasingly used in routine medical diagnostics. It happened because LC-MS methods for determining markers of metabolic disorders provide unique sensitivity and selectivity. However, a significant disadvantage of th… More

• Promoter Ph.D., D.Sc. Katarzyna Monika Pawlak
• Keywords: Diagnostyka medyczna | LC-MS | Metabolomika celowana | Sucha kropla krwi |

Nowoczesne techniki sprzężone umożliwiają identyfikację i oznaczanie substancji aktywnych w produktach i … More

• Promoter Ph.D., D.Sc. Katarzyna Monika Pawlak
• Keywords: Spektrometria mas | Techniki rozdzielania | | | Farmakologia | Substancje aktywne |

Single particle microwave induced plasma optical emission spectrometry (sp-MWP-OES) is a unique, multi-purpose analytical technique, developed in our lab for multielement analysis of nanopowders. It can be applied for the investigation of particle-by particle reproducibility of chemical composition… More

• Promoter prof. Krzysztof Jan Jankowski
• Keywords: Analiza w trybie pojedynczej cząstki | Nanomateriały | Plazma indukowana mikrofalami | Spektrometria optyczna |