Wykaz obszarów badawczych związanych z tagiem Diagnostyka-medyczna:
| # | Obszar badawczy | Dziedzina naukowa |
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| 1 |
Mass spectrometry combined with liquid chromatography-mass spectrometry (LC-MS) is increasingly used in routine medical diagnostics. It happened because LC-MS methods for determining markers of metabolic disorders provide unique sensitivity and selectivity. However, a significant disadvantage of this technique is the need to deliver body fluids to the analytical laboratory. As a result, methods are being developed to determine metabolites in a dry blood sample (DBS). A drop of blood can be applied to blotting paper, dried by the patient, and then sent to the laboratory. The determination of metabolites by LC-MS can be automated and leads to a significant reduction in analysis costs. The work carried out in this area requires the development of methods to determine metabolite groups specific to the selected disease. During the work, it is necessary to consider the stability and degree of homogeneity of tested samples to obtain a sensitive and reproducible analytical method.
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| 2 |
I invite doctoral students and researchers interested in harnessing the latest technologies in medicine to collaborate. My work is interdisciplinary, offering the opportunity to engage in both fundamental and applied research. The goal is not just to hone your analytical and programming skills but to make a genuine contribution to advancements in medical diagnostics. Moreover, the research is conducted in collaboration with real medical centers, such as hospitals and specialized clinics. This ensures that the outcomes of our studies have a realistic chance for rapid clinical implementation, enhancing their direct impact on the quality and effectiveness of medical care.
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| 3 |
The evolutionarily directed affinity of nucleic acids and antibodies toward the corresponding analytes (complementary sequences, antigens) makes them applicable, among other things, as receptors for biosensing layers of affinity biosensors. Molecular recognition occurring in several nanometer interfacial space (surface/solution) translates into a very strong response of biological sensors and obtaining low detection limits or very high sensitivity of conducted analyses. Research topics include the design and analysis of receptor layers of affinity biosensors (nucleic acids, including aptamers and antibodies) as well as the design of ready-to-use sensor solutions, including those manufactured using substrates in printed electronics technology. Such solutions, due to a high degree of miniaturization, the ability to simultaneously detection up to a dozen analytes, low cost or freedom in production scalability, have a high degree of application through integration into modern microfluidic devices and ultimately into POC type diagnostic tools.
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