Wykaz obszarów badawczych związanych z tagiem Biosensory:
| # | Obszar badawczy | Dziedzina naukowa |
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| 1 |
The research objective is the elaboration of affinity-based receptor layers for detection of analytes that are environmentally and clinically important. In the developed biosensors the recognition layers are formed of antibodies, nucleic acids and aptamers and detection techniques that are applied in such constructs are electrochemical, quarz - crystal microbalance and surface plasmon resonance. Functional nucleic acids are especially interesting as receptor elements and they include molecules such as aptamers and DNAzymes that exhibit catalytic and receptor features. Such receptor layers can be utilized for detection of e.g. metal cations, proteins and miRNA. The aim is to elaborate receptor layers that would selectively bind to target analytes and they would allow to obtain working parameters that would be advantageous in comparison to classical detection techniques.
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| 2 |
Synthesis, studies on properties and application of nanoparticles in the construction of biotests and biosensors - the research will involve synthesizing hybrid nanoparticles with the desired magnetic, optical and catalytic properties, which after surface modification with selected receptors (antibodies, oligonuclotides or others) will be used in the development of modern bioanalytical tools for determination of clinically significant disease biomarkers.
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| 3 |
Studies on interactions of clinically significant analytes with the receptor layers using label-free analytical techniques - the research will be focused on investigations of new receptors enabling the development of biosensors and biotests for the detection or determination of clinically relevant analytes (mainly disease biomarkers). The research will be based on techniques enabling the determination of kinetic and thermodynamic parameters of interactions used in the construction of such devices (bioreceptor - biomarker), e.g. SPR.
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| 4 |
Development of innovative, advanced sensing solutions, in particular for biosensing applications. The sensors benefit from unique properties of applied optical fibers and thin films. As a team, within recent years we have developed advanced technological and measurement capabilities, as well as gained world-wide recognized experience within thin film technology and optical fiber sensing techniques. We work on design (numerical analysis), fabrication (thin film technology, surface processing and functionalization), measurements (surface analysis; optical, electrochemical and biosensing measurements) and applications (collaboration with industrial and scientific partners, including mechanics, physicists, material scientists, chemists, biologist and medics). Additionally, we design and fabricate optoelectronic systems for analysis of response of developed sensors, as well as tune a wide gamut of thin film deposition techniques towards their custom applications.
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| 5 |
The use of electrospun materials in the construction of modern bioanalytical tools - Electrospinning is a modern technique for producing polymeric mats (both from natural and synthetic polymers) with an expanded surface area and high porosity. The method also makes it possible to produce composite structures enriched with nanoparticles, which boosts their range of applications by giving them new properties. Such mats can be utilized in bulk technologies (catalytic processes or wastewater treatment) or for more sophisticated biomedical or bioanalytical applications. Their numerous unique features also allow their use in the construction of biosensors and biotesters as transducer modifiers, as well as layers in/on which the most important receptors, from the point of view of these bioanalytical devices, are immobilized.
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| 6 |
The evolutionarily directed affinity of nucleic acids and antibodies toward the corresponding analytes (complementary sequences, antigens) makes them applicable, among other things, as receptors for biosensing layers of affinity biosensors. Molecular recognition occurring in several nanometer interfacial space (surface/solution) translates into a very strong response of biological sensors and obtaining low detection limits or very high sensitivity of conducted analyses. Research topics include the design and analysis of receptor layers of affinity biosensors (nucleic acids, including aptamers and antibodies) as well as the design of ready-to-use sensor solutions, including those manufactured using substrates in printed electronics technology. Such solutions, due to a high degree of miniaturization, the ability to simultaneously detection up to a dozen analytes, low cost or freedom in production scalability, have a high degree of application through integration into modern microfluidic devices and ultimately into POC type diagnostic tools.
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