Wykaz obszarów badawczych związanych z tagiem Uklady-mikroprzeplywowe:
| # | Obszar badawczy | Dziedzina naukowa |
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| 1 |
Fast molecular diagnostics based on nucleic acid analysis enables the detection not only diseases caused by mutations in genes or the identification of pathogenic microorganisms but also the selection of an appropriate treatment method for each patient. Its development is related to the latest achievements in the field of microfluidic systems and integrated sensors and biosensors. This combination allows for efficient and fully automatic preparation of biological material samples and their analysis.
At this area research is focused on the development of new electrochemical sensors dedicated to effective and selective detection of selected nucleic acid sequences. In particular, samples derived from isothermal DNA amplification reactions will be considered. The high content of proteins in such samples force the use of new approaches leading to the elimination of their influence on the processes taking place at the electrode/solution interface. In particular, this applies to selected nanomaterials and elements of biosensitive receptor layers that eliminates the possibility of non-specific protein adsorption.
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| 2 |
The PhD thesis will focus on developing a research methodology combining Organ-on-Chip technology with high-resolution mass spectrometry to monitor interorgan communication and assess therapy efficacy and safety. The project will develop multi-organ microfluidic systems that replicate the physiological connections between selected tissues, including the liver, and drug target tissues. The use of mass spectrometry will enable the quantitative analysis of metabolites, biomarkers, and drug biotransformation products in real time. The result will be a comprehensive methodology supporting preclinical research, identifying mechanisms of drug action, and predicting their efficacy and systemic toxicity.
Additional information Assistant supervisor: dr inż. Agnieszka Żuchowska.
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