Wykaz obszarów badawczych związanych z tagiem Biosensors:
| # | Obszar badawczy | Dziedzina naukowa |
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| 1 |
Integration of Metal-Organic Frameworks and Two-Dimensional Materials for Advanced Biosensing Applications
The development of novel sensing technologies is of paramount importance for human health monitoring. Biosensors are an excellent choice for fast, accurate, and inexpensive diagnostics, while electrochemical sensing is the key enabling technology for multiplex sensing and integration into future telemedicine concepts. The proposed PhD research aims to explore the synergistic combination of metal-organic frameworks (MOFs) and two-dimensional (2D) materials to develop innovative biosensing technologies for human health monitoring. Integrating MOFs and 2D materials will enable a unique platform that leverages the advantages of both materials, leading to enhanced sensitivity, selectivity, and stability in biosensor design.
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| 2 |
The use of electrospun materials in the construction of modern bioanalytical tools - Electrospinning is a modern technique for producing polymeric mats (both from natural and synthetic polymers) with an expanded surface area and high porosity. The method also makes it possible to produce composite structures enriched with nanoparticles, which boosts their range of applications by giving them new properties. Such mats can be utilized in bulk technologies (catalytic processes or wastewater treatment) or for more sophisticated biomedical or bioanalytical applications. Their numerous unique features also allow their use in the construction of biosensors and biotesters as transducer modifiers, as well as layers in/on which the most important receptors, from the point of view of these bioanalytical devices, are immobilized.
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| 3 |
The evolutionarily directed affinity of nucleic acids and antibodies toward the corresponding analytes (complementary sequences, antigens) makes them applicable, among other things, as receptors for biosensing layers of affinity biosensors. Molecular recognition occurring in several nanometer interfacial space (surface/solution) translates into a very strong response of biological sensors and obtaining low detection limits or very high sensitivity of conducted analyses. Research topics include the design and analysis of receptor layers of affinity biosensors (nucleic acids, including aptamers and antibodies) as well as the design of ready-to-use sensor solutions, including those manufactured using substrates in printed electronics technology. Such solutions, due to a high degree of miniaturization, the ability to simultaneously detection up to a dozen analytes, low cost or freedom in production scalability, have a high degree of application through integration into modern microfluidic devices and ultimately into POC type diagnostic tools.
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| 4 |
Advanced Microfluidic and Organ-on-Chip Systems in Biotechnology and Precision Medicine – research focuses on the design, fabrication, and application of innovative microfluidic platforms and Organ-on-Chip (OoC) systems, which enable the creation of biomimetic models of human tissues and organs. These models enable the study of disease mechanisms, interactions between different cell types, and the testing of new therapies in a controlled laboratory environment. This area encompasses the development of microfabrication technologies (photolithography, micromilling, 3D printing, thin-film lamination), the design of microenvironments supporting cell co-cultures, and the integration of real-time cell function monitoring systems (e.g., TEER/EIS techniques, fluorescence imaging, molecular methods). These platforms are used in basic research, toxicology, pharmacology, and precision medicine, contributing to the development of a new generation of in vitro models that better represent human physiology.
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Design and development of integrated point-of-care systems for biomedical diagnostics – this research area encompasses the development of modern, miniaturized point-of-care (POC) diagnostic devices that integrate sample preparation, analysis, and result reading functions into a single system. Research focuses on the design of disposable microfluidic systems (cassettes, cartridges, LFA test strips) and the construction of autonomous readers enabling diagnostic testing directly at the patient. This includes the development of integrated flow management systems (micropumps, microvalves, microfluidic channels), measurement electronics, control software, and user interfaces. Particular emphasis is placed on the integration of biosensors (e.g., electrochemical, optical) with microfluidic platforms and the automation of the entire diagnostic process. The technologies being developed are used in companion diagnostics, oncology, cardiovascular diseases, and many other conditions requiring rapid and precise biomarker detection. Furthermore, the systems being developed can be adapted to detect infectious agents, including viruses, bacteria, and parasites, enabling their use in the rapid diagnosis of infectious diseases in clinical settings, in the field, and during crisis situations. Such platforms also have potential for diagnostic applications in the military, emergency services, and combat medicine, where mobility, speed, independence from laboratory infrastructure, and the ability to operate in challenging environmental conditions are essential.
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