Doctoral Schools WUT

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Wykaz obszarów badawczych związanych z tagiem Biomaterialy:

# Obszar badawczy Dziedzina naukowa
1 The topic is related to the search for new materials for tissue reconstruction. We will focus on polymers containing glycerin and unsaturated polycarboxylic acids in their structure. Such materials can be easily introduced into aza- and thio-Michael reactions under mild conditions. As a result of these processes, it is possible to obtain porous three-dimensional polymer networks for use in non-invasive prophylaxis of osteoporotic fractures. I plan to develop a material in the form of a low-viscosity liquid polymer that can be introduced non-invasively (with a thin needle) into the spongy bone of reduced density. The next in the same opening would be the introduction of the cross-linking agent with bone or stem cells. In the bone defect, cross-linking and strengthening of this fragment would take place. After the healing time has elapsed, the polymeric material would be resorbed and the cells would naturally rebuild the spongy bone. Another application of the developed materials would be the reconstruction of soft tissues, e.g. blood vessels or the heart muscle.
2 Electrospun polymer structures for the manufacturing of biomaterials An important aspect of tissue engineering is the ability to imitate the fibrous extracellular matrix (ECM) in the way that fundamental principles of cell organization, survival, and function can be provided. One of the most important methods for the mimicking ECM is electrospinning. The doctoral thesis will cover the preparation of new polymeric biomaterials for medical applications (e.g. tissue scaffolds) using the electrospinning technique. As part of the research, the PhD candidate will synthesize new polymer structures based on carbon dioxide derivatives, and then optimize the parameters of the electrospinning process of nanofiber mats. An important aspect of the work will be the characterization of obtained structures, such as: assessment of the morphology of fibers, their porosity, strength, thermal and thermomechanical properties, biodegradability and biocompatibility. As part of the planned research, it will be possible to complete a research internship abroad.
3 Research focuses on the development and characterization of advanced biomaterials for implantology, tissue engineering and drug delivery systems.