Wykaz obszarów badawczych związanych z tagiem Organ-on-chip:
| # | Obszar badawczy | Dziedzina naukowa |
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| 1 |
Advanced Microfluidic and Organ-on-Chip Systems in Biotechnology and Precision Medicine – research focuses on the design, fabrication, and application of innovative microfluidic platforms and Organ-on-Chip (OoC) systems, which enable the creation of biomimetic models of human tissues and organs. These models enable the study of disease mechanisms, interactions between different cell types, and the testing of new therapies in a controlled laboratory environment. This area encompasses the development of microfabrication technologies (photolithography, micromilling, 3D printing, thin-film lamination), the design of microenvironments supporting cell co-cultures, and the integration of real-time cell function monitoring systems (e.g., TEER/EIS techniques, fluorescence imaging, molecular methods). These platforms are used in basic research, toxicology, pharmacology, and precision medicine, contributing to the development of a new generation of in vitro models that better represent human physiology.
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| 2 |
The PhD thesis will focus on developing a research methodology combining Organ-on-Chip technology with high-resolution mass spectrometry to monitor interorgan communication and assess therapy efficacy and safety. The project will develop multi-organ microfluidic systems that replicate the physiological connections between selected tissues, including the liver, and drug target tissues. The use of mass spectrometry will enable the quantitative analysis of metabolites, biomarkers, and drug biotransformation products in real time. The result will be a comprehensive methodology supporting preclinical research, identifying mechanisms of drug action, and predicting their efficacy and systemic toxicity.
Additional information Assistant supervisor: dr inż. Agnieszka Żuchowska.
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