Wykaz obszarów badawczych:
| # | Research Area | Dziedzina naukowa |
|---|---|---|
| 1 |
The research objective is the elaboration of affinity-based receptor layers for detection of analytes that are environmentally and clinically important. In the developed biosensors the recognition layers are formed of antibodies, nucleic acids and aptamers and detection techniques that are applied in such constructs are electrochemical, quarz - crystal microbalance and surface plasmon resonance. Functional nucleic acids are especially interesting as receptor elements and they include molecules such as aptamers and DNAzymes that exhibit catalytic and receptor features. Such receptor layers can be utilized for detection of e.g. metal cations, proteins and miRNA. The aim is to elaborate receptor layers that would selectively bind to target analytes and they would allow to obtain working parameters that would be advantageous in comparison to classical detection techniques.
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Chemical-Sciences |
| 2 | Fast molecular diagnostics based on nucleic acid analysis enables the detection not only diseases caused by mutations in genes or the identification of pathogenic microorganisms but also the selection of an appropriate treatment method for each patient. Its development is related to the latest achievements in the field of microfluidic systems and integrated sensors and biosensors. This combination allows for efficient and fully automatic preparation of biological material samples and their analysis. At this area research is focused on the development of new electrochemical sensors dedicated to effective and selective detection of selected nucleic acid sequences. In particular, samples derived from isothermal DNA amplification reactions will be considered. The high content of proteins in such samples force the use of new approaches leading to the elimination of their influence on the processes taking place at the electrode/solution interface. In particular, this applies to selected nanomaterials and elements of biosensitive receptor layers that eliminates the possibility of non-specific protein adsorption. | Chemical-Sciences |