Wykaz obszarów badawczych związanych z tagiem Rozpuszczalnosc:
| # | Obszar badawczy | Dziedzina naukowa |
|---|---|---|
| 1 |
Physicochemical properties play an important role in designing drugs, and also in the optimization process of the pharmaceutical product. The problem of low pharmaceuticals’ solubility became more significant, due to drugs in new therapeutic areas.
- Determination the basic physicochemical properties of the API (Active Pharmaceutical Ingredient).
- Selection of poorly soluble therapeutic substances based on phase equilibria in binary systems (solid-liquid equilibrium); correlation of experimental data using a GE model to describe the solubility curves. Determination of significant physicochemical properties.
- Measurements pKa.
- Determination of the solubility of the unionized form of API and profiling solubility in water as a function of pH.
- Analysis to improve the solubility of sparingly soluble drugs by cyclodextrins complexation - improving the bioavailability of the drug in the human body.
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