Wykaz obszarów badawczych:
| # | Research Area | Dziedzina naukowa |
|---|---|---|
| 1 |
Spectroscopic ""fingerprints"" of cells – acquisition and numerical analysis.
Thanks to their uniqueness, fingerprints are one of the basic biometric features used to identify people. Identification techniques in chemistry can also rely on the recognition of ""patterns"" - that is, signal patterns that are unique to a given sample. Two-dimensional fluorescence (2DF) is one of the identification techniques that has gained popularity in recent years. The 2DF spectrum encodes information on all fluorescent substances present in the sample (e.g. amino acids, oligopeptides, structural proteins, enzymes, vitamins, lipids, porphyrins). Information hidden in such a ""fingerprint"" has to be decoded by numerical processing, often involving machine learning methods. In the frame of the proposed doctorate we plan to use two-dimensional fluorescence to create ""fingerprints"" of cell cultures that will serve for the recognition of the overall cellular response to various physical and / or chemical stimuli.
|
Chemical-Sciences |
| 2 |
""Fingerprints"" of quantum dots for analytical and bioanalytical purposes.
The subject of the PhD thesis is related to the use of nanomaterials - quantum dots - to create fluorescent ""fingerprints"" for the identification / determination of selected bioanalytes with a similar structure: amino acids, oligopeptides, neurotransmitters, hormones, nucleosides, and metabolites. Recognition by means of a unique pattern hidden in such a ""fingerprint"" is an alternative to classical molecular recognition based on the principle of lock and key and requires the desired information to be decoded using numerical methods. The aim of the doctorate will be to design, develop and determine the analytical capabilities of quantum dot arrays that have the potential to create useful bioanalytical tools. The proposed methodology has great potential as a quick, universal, easy-to-perform test that can be used in medical diagnostics, systems biology, proteomics and metabolomics studies.
|
Chemical-Sciences |
| 3 |
Ion-sensitive nano- and microspheres - fabrication, characterization and testing of sensory properties.
In recent years, nanotechnology has developed a number of tools enabling the fabrication, characterization, and study of the potential applications of a number of nanomaterials, which we use more and more in everyday life. One of the research areas intensively explored are biomedical applications of nanomaterials, including the use of their sensitivity to their microenvironment, which results in the possibility of detection and quantification of a number of bioanlites and the possibility of in vivo and in vitro bioimaging. The aim of the doctorate will be to design ion-sensitive nano- and microspheres with the desired chemosensory properties and to study their potential applications in biological samples.
|
Chemical-Sciences |
| 4 |
Electronic tongue - study of the correlation of (soft) sensor signals with organoleptic properties.
The ""Holy Grail"" of the pharmaceutical and food industry is the replacement of trained organoleptic evaluation experts (human panel) with machine-based taste and smell systems, so-called taste and smell sensors, also known as ""electronic noses"" and ""electronic tongues"". Over the last years, we have gained unique expertise in this field - we are able to develop biomimetic systems with which we can identify bitter taste masking in pediatric formulations, determine the method of food processing used to increase shelf life of foodstuff, or evaluate the effectiveness of artificial sweeteners. The aim of the doctorate will be the fabrication of (soft) sensors / (soft) sensor arrays and the acquisition of their signals, for further data mining aiming on correlating the signals with the organoleptic properties of selected foodstuff and / or pharmaceutical products.
|
Chemical-Sciences |