Wykaz obszarów badawczych:
| Obszar badawczy | Dziedzina naukowa |
Mass spectrometry combined with liquid chromatography-mass spectrometry (LC-MS) is increasingly used in routine medical diagnostics. It happened because LC-MS methods for determining markers of metabolic disorders provide unique sensitivity and selectivity. However, a significant disadvantage of this technique is the need to deliver body fluids to the analytical laboratory. As a result, methods are being developed to determine metabolites in a dry blood sample (DBS). A drop of blood can be applied to blotting paper, dried by the patient, and then sent to the laboratory. The determination of metabolites by LC-MS can be automated and leads to a significant reduction in analysis costs. The work carried out in this area requires the development of methods to determine metabolite groups specific to the selected disease. During the work, it is necessary to consider the stability and degree of homogeneity of tested samples to obtain a sensitive and reproducible analytical method.
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Chemical-Sciences |
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