Wykaz obszarów badawczych:
| # | Research Area | Dziedzina naukowa |
|---|---|---|
| 1 |
Melanoma is the skin cancer with the highest mortality and increasing incidence in the world population. Despite many years of efforts, there is no effective therapy for metastasis of this cancer and a lot of research is devoted to searching for new solutions using the modern methods and technologies to overcome this risk. One strategy is to apply in silico computational methods using available databases to identify the most promising drug combinations and novel substances known as cell signaling effectors. As part of the project, for the biophysical tests of melanoma cells, label-free methods (e.g. quartz microbalance extended with a module enabling the simultaneous registration of changes in the refractive index) and the methods measuring changes in biochemical parameters will be used. The correlation of the experimental data with the bioinformatic analysis will allow the selection of the best combinations.
|
Chemical-Sciences |
| 2 |
Exosomes are extracellular signaling molecules secreted by eukaryotic cells, the presence of which in body fluids makes them a potential and easily accessible biomarkers of various pathological processes, including cancer. Taking blood serum rich in exosomes from patients with cancer is a simple and minimally invasive procedure. Methods for detecting exosomes can be used not only to monitor the stage of a given tumor, but also to assess the effectiveness of the applied therapy, including immunotherapy, targeted or combined therapy. The aim of the project is to optimize a specific method of isolation and determination of the content exosomes in blood samples from patients in order to monitor the therapy of cancer.The project is implemented in cooperation with Charité - Universitätsmedizin Berlin as part of the "Institutpartnerschaft" program granted by Alexander von Humboldt foundation.
|
Chemical-Sciences |